The BMT OZONE EXPOSURE SYSTEM OES 1.0 for controlled ozone breathing has been developed for COPD drug profiling. Two subjects can breathe air with a precisely controlled ozone content to be preset between 100 and 400 ppbv, and precisely controlled humidity. The desired result is artificially induced airway inflammation, and induced sputum.  

Literature:
[Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development,
Kai Richter et alii, J Clin Pharmcol 2005;45:498-503]